Study findings from Chulalongkorn University, Department of Biology broaden understanding of breast cancer animal studies

HighBeam Research

Title: Study findings from Chulalongkorn University, Department of Biology broaden understanding of breast cancer animal studies.

Date: January 28, 2008 Publication: Health & Medicine Week

Current study results from the report, ‘Pretreatment with phytoestrogen-rich plant decreases breast tumor incidence and exhibits lower profile of mammary ERalpha and ERbeta,’ have been published (see also Breast Cancer Animal Studies). “Phytoestrogens have been reported to exhibit antiproliferation to human breast cancer cells in vitro. We tested the phytoestrogen-rich, Pueraria mirifica against rat breast cancer induction in vivo,” scientists in Bangkok, Thailand report.

“The weanling female Spargue-Dawley rats were pretreated with P. mirifica tuberous powder at a dosage of 0, 10, 100 and 1000 mg/kg BW/day for four consecutive weeks. Mammary tumor development was then induced with a single dose of 7,12-DMBA, 80 mg/kg BW, followed by a weekly examination for size and multiplicity of mammary tumors for 20 weeks and finally a necropsy. Mammary tissues were investigated for the virulence of tumor and also monoclonal antibody stained against ERalpha and ERbeta. Pretreatment of 1000 mg/(kgBWday) of P. mirifica tuberous powder resulted in decreasing of the virulence of rat tumor development,” wrote W. Cherdshewasart and colleagues, Chulalongkorn University, Department of Biology.

The researchers concluded: “The mammary tumor tissues exhibited lower profile of ERalpha and ERbeta as well as ERalpha/ERbeta. P. mirifica exhibited prevention of 7,12-DMBA-induced rat mammary tumors, with a proposed mechanism of strong competitive binding of its phytoestrogens to ERalpha and/or synthesis suppressor of ERalpha.”

Cherdshewasart and colleagues published their study in Maturitas (Pretreatment with phytoestrogen-rich plant decreases breast tumor incidence and exhibits lower profile of mammary ERalpha and ERbeta. Maturitas, 2007;58(2):174-81).

For additional information, contact W. Cherdshewasart, Faculty of Science, Dept. of Biology, Chulalongkorn University, Phyathai Road, Patumwan, Bangkok 10330, Thailand.

The publisher’s contact information for the journal Maturitas is: Elsevier Science Ireland Ltd., Customer Relations Manager, Bay 15, Shannon Industrial Estate, Co. Clare, Ireland.

Keywords: Thailand, Bangkok, Breast Cancer Animal Studies, Alternative Medicine, Breast Cancer, Breast Carcinoma, Breast Tumors, Endocrinology, Estrogen, Hormones, Oncology, Therapy, Treatment, Women’s Health.

This article was prepared by Health & Medicine Week editors from staff and other reports. Copyright 2008, Health & Medicine Week via NewsRx.com.

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