Scientists at Gunma University, Medical Department publish new data on menopause. (Report)

Scientists at Gunma University, Medical Department publish new data on menopause. (Report)

HighBeam Research

Title: Scientists at Gunma University, Medical Department publish new data on menopause.(Report)

Date: February 19, 2009 Publication: Women’s Health Weekly

“Impaired lipid metabolism is all important health problem in postmenopausal women with insufficient estrogens, because dyslipidemia is a risk factor for development of atherosclerosis and the incidence of cardiovascular disease markedly increases after menopause. Pueraria mirifica (PM), a Thai herb, has been noticed as a Source of phytoestrogens, estrogen-mimicking plant compounds,” scientists in Maebashi, Japan report (see also Menopause).

“However, the clinical effects of PM on lipid metabolism and the underlying molecular mechanisms remain undetermined. Therefore, we examined the effects of PM oil serum lipid parameters in a randomized, double-blind, placebo-controlled clinical trial. Nineteen postmenopausal women were randomly assigned to receive oral administration of FM powder or placebo. After 2 months of treatment, the PM group showed a significant increase in serum concentrations of high-density lipoprotein (HDL) cholesterol and apolipoprotein (apo) A-1 (34% and 40%, respectively), and a significant decrease in low-density lipoprotein (LDL) cholesterol and apo B (17% and 9%, respectively), compared with baseline measurements. Moreover, significant decreases were observed in the ratios of LDL cholesterol to HDL cholesterol (37%) and apo B to apo A-1 (35%). Next, we determined the effects of PM phytoestrogens oil the activation of estrogen receptor (ER)-mediated transactivation by transient expression assays of a reporter gene in cultured cells. Among PM phytoestrogens, miroestrol and coumestrol enhanced both ER alpha- and ER beta-mediated transactivation, whereas other phytoestrogens, including daidzein and genistein, preferentially enhanced ER beta-mediated transactivation,” wrote S. Okamura and colleagues, Gunma University, Medical Department.

The researchers concluded: “PM has a beneficial effect on lipid metabolism in postmenopausal women, which may result from the activation of gene transcription through selective binding of phytoestrogens to ER alpha and ER beta.”

Okamura and colleagues published their study in Tohoku Journal of Experimental Medicine (Pueraria Mirifica Phytoestrogens improve Dyslipidemia in Postmenopausal Women Probably by Activating Estrogen Receptor Subtypes. Tohoku Journal of Experimental Medicine, 2008;216(4):341-351).

For more information, contact T. Sakamaki, Gunma University, School Medical, Dept. of Med Informat & Decis Science, Maebashi, Gumma 3718511, Japan.

Publisher contact information for the Tohoku Journal of Experimental Medicine is: Tohoku University Medical Press, School of Medicine, Sendai, 980-77, Japan.

Keywords: Japan, Maebashi, Alternative Medicine, Atherosclerosis, Cardiology, Cardiovascular Disease, Clinical Trial Research, Dyslipidemias, Endocrinology, Estrogen, Experimental Medicine, Hormones, Menopause, Metabolism, Therapy, Treatment, Gunma University, Medical Department.

This article was prepared by Women’s Health Weekly editors from staff and other reports. Copyright 2009, Women’s Health Weekly via


This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group.

This document provided by HighBeam Research at